Fig. 4.
Endothelial Fgfr1 and Fgfr2 ablation does not affect CD45-positive cell number after I/R injury. A: representative images of CD45-positive cells in the peri-infarct area of control and Tie2-Cre, Fgfr1f/f, Fgfr2f/f DCKO mice after I/R injury (green: CD45; blue: DAPI). Scale bar = 20 μm. B: quantitation of CD45-positive cells showing significantly increased numbers at 3 days and significantly decreased numbers at 7 days after I/R injury compared with 1 day after I/R injury in both control and Tie2-Cre, Fgfr1f/f, Fgfr2f/f DCKO hearts. There is no significant difference in CD45-positive cell number between control and Tie2-Cre, Fgfr1f/f, Fgfr2f/f DCKO hearts at any time point. #P < 0.01 vs. 1-day time point; n = 4–8.