Fig. 6.
Endothelial Fgfr1 and Fgfr2 are required for vascular remodeling after I/R injury. A: representative images of immunofluorescence for α-smooth muscle actin (red) and nuclei (DAPI: blue) in the peri-infarct area of the LV. Scale bar = 100 μm. B: after I/R injury, there is a significant decrease in the number of vessels in the peri-infarct area and Tie2-Cre, Fgfr1f/f, Fgfr2f/f DCKO hearts show decreased vessel density compared with controls at 7 days after I/R injury. C: there are not significant differences in vessel diameter in any treatment group. *P < 0.05 vs. control; #P < 0.05 vs. sham; n = 4–8.