Fig. 5.

CPP in rats before (day 1) and after training with a palatable food reward (day 8) and after IIH (day 13) preceded by 3 previous bouts of home cage hypoglycemia (RH) or saline injections (SH). A: CPP is expressed as the difference in time spent on either side of a 2-sided CPP apparatus. Change in the sign of the CPP value reflects a change in preference relative to the previous time point. B: preproorexin mRNA relative abundance in the PFH and LHA in recurrent hypoglycemic or single hypoglycemic rats. Data are means ± SE; *P ≤ 0.05 between groups. Letters denote significant differences in treatment × time by 2-way repeated-measures ANOVA. F(5,4) = 5.3 (day 13, SH vs. RH).