Fig. 6.

CPP in rats before (day 1) and after (day 8) training with a palatable food reward and after IIH (day 10) or saline paired with SB-334867A (20 mg/kg ip) or vehicle. CPP is expressed as the difference in time spent on either side of a 2-sided CPP apparatus. Change in the sign of the CPP value reflects a change in preference relative to the previous time point. Data are means ± SE. Letters denote significant differences in treatment × time by 2-way repeated-measures ANOVA. F(3,3) = 2.8 (day 13, Hypo-SB vs. Sal-SB/Sal-DMSO); F(3,2) = 6.6 (day 13, Hypo-DMSO vs. Sal-SB/Sal-DMSO).