Table 1.
Parameters used in the model
| Symbol, Unit | Source | |
|---|---|---|
| Estimated parameters | ||
| Muscle plasma volume | V1, ml/kg | |
| Muscle interstitial volume | V2, ml/kg | |
| Permeability-surface product | PS, ml/min | |
| Intrinsic hepatic clearance | CLint,L, ml/min | |
| Intrinsic renal clearance | CLint,K, ml/min | |
| Basal delivery rate | Ibasal, mU/min | |
| Peak delivery rate | Iphase1, mU/min | |
| Derived parameters | ||
| Hepatic clearance | CLhep, ml/min | Eq. 1 |
| Renal clearance | CLren, ml/min | |
| Hepatic extraction | Ehep, % | Eq. 2 |
| Total insulin delivery | TID, U | Eq. 3 |
| Total insulin secretion | TIS, U | Eq. 4 |
| Parameters derived from fixed ratios | ||
| Lung plasma volumea | VP | V1·1.1 |
| Gut plasma volumeb | VG | V1·0.34 |
| Liver plasma volumec | VL | V1·0.17 |
| Kidney plasma volumed | VK | V1·0.05 |
| Cardiac plasma outpute | Q | 4000·(BW/70)0.71 |
| Flow fraction to hepatic arteryf | qH,a | Q·0.08 |
| Flow fraction to portal vein | qPv | Q·0.20 |
| Flow fraction to kidney | qK | Q·0.17 |