Table 2.
Population parameter estimates for the model of insulin distribution, elimination and secretion dynamics in patients undergoing an intravenous glucose tolerance test
| Model Parameter | Symbol, Unit | Mean (%RSE) | Interpatient CV% (%RSE) |
|---|---|---|---|
| Muscle blood volumea | V1, ml/kg | 19.1 (6) | 49 (9) |
| Muscle interstitial volumea | V2, ml/kg | 24.9 (17) | 81 (22) |
| Permeability-surface product | PS, ml/min | 75.8 (13) | 64 (21) |
| Intrinsic hepatic clearance | CLint,L, ml/min | 571 (22) | 67 (27) |
| Intrinsic renal clearance | CLint,K, ml/min | 171 (51) | 65 (53) |
| Basal delivery rate | Ibasal, mU/min | 2.93 (10) | 80 (9) |
| Peak delivery rate | Iphase1, mU/min | 61.2 (8) | 73 (10) |
| Hepatic clearanceb | CLhep, ml/min | 363 | 42 |
| Renal clearanceb | CLren, ml/min | 141 | 54 |
| Hepatic extractionb | Ehep, % | 46 | 36 |
| Total insulin deliveryb | TID, U | 0.397 | 73 |
| Total insulin secretionb | TIS, U | 0.730 | 85 |
a
These volumes include muscle and all other tissues with the exception of the hepatosplanchnic organs and kidneys.
b
The equations for these derived parameters are presented in materials and methods.