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. 2016 Mar 18;6:23148. doi: 10.1038/srep23148

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Ct is able to recruit host-cell ACSLs and host straight-chain FAs into the chlamydial inclusion, and synthetize its own branched-chain FAs iso-C15:0 and anteiso-C15:0. FAs must be activated to acyl-CoA before they can be incorporated into phospholipids. Because acyl-CoA is not able to cross the inclusion membrane, activation must occur inside the chlamydial inclusion. We propose that host ACSL1, 3, 4, 5 and 6 are recruited into the chlamydial inclusion to activate both host straight-chain FAs and Ct branched-chain FAs.