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. 2016 Mar 18;6:23138. doi: 10.1038/srep23138

Figure 4. MxA escape of KAN-1_3x is influenced by the additional mutations in NP.

Figure 4

(A) A549-MxA cells were treated with siRNAs targeting MxA (siMxA) or a non-targeting siRNA (siCtr). Three days post transfection, cells were infected with wild-type KAN-1 (KAN-1) or the indicated mutant viruses at a MOI of 0.001 and virus titers were determined by plaque assay 48 hours post infection. Error bars indicate the standard deviation from the mean of 3 independent experiments. Fold differences in virus titers are indicated. (B–D) A459 cells expressing (MxA) or lacking MxA (shMxA) were infected at an MOI of 0.001 of wild-type KAN-1 (KAN-1) or the indicated mutant viruses. At the indicated hours post infection (h.p.i.), virus titers were determined by plaque assay. Error bars indicate the standard deviation of the mean of 3 independent experiments. Fold differences in virus titers are indicated.