Table 1. Vulnerability of different nodes in the survival pathway (%) under deterministic drug delivery.
| Strategy | Sub-1 | Sub-2 | Sub-3 | JAK2 | Stat3 | NFkB | S6K | elF4E | JUN | FOS | Myc | Mcl1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | 5% | 70% | 25% | 4.35% | 3.68% | 0 | 61.20% | 0 | 21.95% | 21.95% | 21.95% | 25.63% |
| #2 | 15% | 70% | 15% | 5.48% | 11.12% | 0 | 61.32% | 0 | 13.21% | 13.21% | 13.21% | 24.33% |
| #3 | 25% | 70% | 5% | 6.67% | 18.61% | 0 | 61.32% | 0 | 4.42% | 4.42% | 4.42% | 23.03% |
| #4 | 20% | 50% | 30% | 8.79% | 14.90% | 0 | 43.86% | 0 | 26.26% | 26.26% | 26.26% | 41.17% |
| #5 | 30% | 50% | 20% | 9.98% | 22.46% | 0 | 43.63% | 0 | 17.54% | 17.54% | 17.54% | 40.00% |
| #6 | 25% | 50% | 25% | 9.41% | 18.77% | 0 | 43.72% | 0 | 21.86% | 21.86% | 21.86% | 40.63% |
| #7 | 50% | 30% | 20% | 14.93% | 37.52% | 0 | 26.14% | 0 | 17.54% | 17.54% | 17.54% | 55.06% |
| #8 | 50% | 20% | 30% | 16.31% | 37.65% | 0 | 17.46% | 0 | 26.17% | 26.17% | 26.17% | 63.82% |
| #9 | 50% | 25% | 25% | 15.53% | 37.45% | 0 | 21.88% | 0 | 21.98% | 21.98% | 21.98% | 59.44% |
| #10 | 70% | 25% | 5% | 18.10% | 52.44% | 0 | 21.99% | 0 | 4.39% | 4.39% | 4.39% | 56.83% |
| #11 | 70% | 5% | 25% | 20.99% | 52.59% | 0 | 4.38% | 0 | 21.94% | 21.94% | 21.94% | 74.53% |
| #12 | 70% | 15% | 15% | 19.29% | 52.53% | 0 | 13.01% | 0 | 13.06% | 13.06% | 13.06% | 65.59% |
| #13 | 70% | 10% | 20% | 29.92% | 52.42% | 0 | 8.72% | 0 | 17.51% | 17.51% | 17.51% | 69.93% |
| #14 | 25% | 5% | 70% | 15.14% | 18.81% | 0 | 4.33% | 0 | 61.36% | 61.36% | 61.36% | 80.17% |
| #15 | 5% | 25% | 70% | 9.83% | 3.70% | 0 | 21.86% | 0 | 61.30% | 61.30% | 61.30% | 65.00% |
| #16 | 15% | 15% | 70% | 12.41% | 11.25% | 0 | 13.11% | 0 | 61.28% | 61.28% | 61.28% | 72.53% |
Each sub-pathway was assigned a different weight percentage, as indicated.
The state of the targeted gene is suppressed to 0. Simulated sequence length is 500 k bits for the stochastic approach.