Table 2. Vulnerability of different nodes in the survival pathway (%) under probabilistic drug delivery.
| Strategy | Sub-1 | Sub-2 | Sub-3 | JAK2 | Stat3 | NFkB | S6K | elF4E | JUN | FOS | Myc | Mcl1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | 5% | 70% | 25% | 2.62% | 2.27% | 0 | 36.92% | 0 | 13.37% | 13.06% | 13.15% | 15.47% |
| #2 | 15% | 70% | 15% | 3.52% | 6.72% | 0 | 36.78% | 0 | 7.66% | 7.78% | 7.89% | 14.67% |
| #3 | 25% | 70% | 5% | 4.18% | 11.08% | 0 | 36.74% | 0 | 2.53% | 2.58% | 2.59% | 13.75% |
| #4 | 20% | 50% | 30% | 5.28% | 8.94% | 0 | 26.29% | 0 | 15.93% | 15.77% | 15.67% | 24.57% |
| #5 | 30% | 50% | 20% | 5.98% | 13.56% | 0 | 26.29% | 0 | 10.40% | 10.47% | 10.34% | 23.88% |
| #6 | 25% | 50% | 25% | 5.60% | 11.16% | 0 | 26.28% | 0 | 13.00% | 13.20% | 13.11% | 24.15% |
| #7 | 50% | 30% | 20% | 8.88% | 22.49% | 0 | 15.85% | 0 | 10.47% | 10.49% | 10.57% | 32.93% |
| #8 | 50% | 20% | 30% | 9.66% | 22.30% | 0 | 10.35% | 0 | 15.87% | 15.63% | 15.85% | 38.12% |
| #9 | 50% | 25% | 25% | 9.60% | 22.72% | 0 | 10.56% | 0 | 13.09% | 13.19% | 13.12% | 35.39% |
| #10 | 70% | 25% | 5% | 10.79% | 31.33% | 0 | 13.18% | 0 | 2.61% | 2.60% | 2.61% | 34.01% |
| #11 | 70% | 5% | 25% | 12.56% | 31.57% | 0 | 2.63% | 0 | 13.19% | 12.93% | 12.98% | 44.65% |
| #12 | 70% | 15% | 15% | 11.89% | 31.59% | 0 | 8.00% | 0 | 7.81% | 7.85% | 7.86% | 39.51% |
| #13 | 70% | 10% | 20% | 11.95% | 31.49% | 0 | 5.30% | 0 | 10.47% | 10.59% | 10.70% | 41.73% |
| #14 | 25% | 5% | 70% | 8.68% | 11.28% | 0 | 2.61% | 0 | 36.74% | 36.72% | 36.55% | 48.05% |
| #15 | 5% | 25% | 70% | 6.04% | 2.26% | 0 | 13.13% | 0 | 36.80% | 36.35% | 36.80% | 38.85% |
| #16 | 15% | 15% | 70% | 7.84% | 6.80% | 0 | 7.94% | 0 | 36.63% | 36.79% | 36.78% | 43.60% |
Each sub-pathway was assigned a different weight percentage, as indicated.
The state of the targeted gene is suppressed to 0, but the suppressing process occurs with a probability of p = 0.6. Simulated sequence length is 500 k bits for the stochastic approach.