Table 3. SNP sites associated with therapeutic responses and ADRs.
| Classification | Gene | SNP | P value | phenotype | Genotype number(frequency) | HWE p value | ||
|---|---|---|---|---|---|---|---|---|
| objective response to drug | EGFR | rs884225 | 0.0226 | T T | T C | C C | ||
| positive | 20(0.333) | 31(0.517) | 9(0.150) | 0.5916 | ||||
| negative | 29(0.175) | 94(0.566) | 43(0.259) | 0.0700 | ||||
| ABCG2 | rs2231142 | 0.0828 | A A | A C | C C | |||
| positive | 8(0.138) | 32(0.552) | 18(0.310) | 0.2959 | ||||
| negative | 11(0.067) | 79(0.482) | 74(0.451) | 0.0955 | ||||
| C C | C T | T T | ||||||
| objective response to erlotinib | CYP2C9 | rs17885098 | 0.0191 | positive | 2(0.062) | 5(0.156) | 25(0.781) | 0.0456 |
| negative | 0(0.000) | 9(0.088) | 93(0.912) | 0.6411 | ||||
| A A | A G | G G | ||||||
| CYP2C19 | rs4986893 | 0.0332 | positive | 1(0.031) | 5(0.156) | 26(0.812) | 0.2628 | |
| negative | 0(0.000) | 5(0.052) | 91(0.948) | 0.7934 | ||||
| A A | A G | G G | ||||||
| AKT1 | rs1130233 | 0.0433 | positive | 2(0.100) | 15(0.750) | 3(0.150) | 0.0243 | |
| negative | 14(0.326) | 18(0.419) | 11(0.256) | 0.2981 | ||||
| C C | C T | C T | ||||||
| positive | — | 2(0.100) | 18(0.900) | 0.8139 | ||||
| miRNA | rs111718468 | 0.0373 | negative | — | 0(0.000) | 42(1.000) | 1.0000 | |
| T T | T C | C C | ||||||
| ADR to TKIs | EGFR | rs884225 | 0.0018 | positive | 23(0.377) | 27(0.443) | 11(0.180) | 0.5367 |
| negative | 26(0.158) | 98(0.594) | 41(0.248) | 0.0111 | ||||
| C C | C T | T T | ||||||
| ABCB1 | rs1045642 | 0.0462 | positive | 28(0.459) | 25(0.410) | 8(0.131) | 0.5239 | |
| negative | 47(0.285) | 92(0.558) | 26(0.158) | 0.0864 | ||||
| A A | A G | G G | ||||||
| ABCB1 | rs10248420 | 0.0434 | positive | 16(0.271) | 30(0.508) | 13(0.220) | 0.8804 | |
| negative | 62(0.403) | 76(0.494) | 16(0.104) | 0.2990 | ||||
| C C | C T | T T | ||||||
| ADR to erlotinib | ABCB1 | rs1128503 | 0.0344 | positive | 4(0.129) | 20(0.645) | 7(0.226) | 0.0922 |
| negative | 12(0.115) | 42(0.404) | 50(0.481) | 0.4889 | ||||
| T T | T C | C C | ||||||
| EGFR | rs884225 | 0.0010 | positive | 15(0.484) | 10(0.323) | 6(0.194) | 0.1000 | |
| negative | 17(0.163) | 60(0.577) | 27(0.260) | 0.0933 | ||||
| A A | A G | G G | ||||||
| ABCB1 | rs7787082 | 0.0356 | positive | 10(0.323) | 11(0.355) | 10(0.323) | 0.1061 | |
| negative | 13(0.125) | 51(0.490) | 40(0.385) | 0.5984 | ||||
| A A | A C | C C | ||||||
| CYP1A2 | rs762551 | 0.0126 | positive | 7(0.233) | 20(0.667) | 3(0.100) | 0.0503 | |
| negative | 50(0.510) | 36(0.367) | 12(0.122) | 0.1805 | ||||
| A A | A G | G G | ||||||
| ABCB1 | rs10248420 | 0.0474 | positive | 8(0.267) | 14(0.467) | 8(0.267) | 0.7150 | |
| negative | 37(0.385) | 50(0.521) | 9(0.094) | 0.1748 | ||||
| ADR to gefitinib | CYP1A1 | rs1048943 | 0.1076 | C C | C T | T T | ||
| positive | 3(0.130) | 10(0.435) | 10(0.435) | 0.8416 | ||||
| negative | 1(0.026) | 12(0.308) | 26(0.667) | 0.7804 | ||||
| skin injury induced by TKIs | EGFR | rs884225 | 0.0073 | T T | T C | C C | ||
| positive | 20(0.370) | 24(0.444) | 10(0.185) | 0.5589 | ||||
| negative | 29(0.169) | 101(0.587) | 42(0.244) | 0.0175 | ||||
| T T | T C | C C | ||||||
| skin injury induced by erlotinib | EGFR | rs884225 | 0.0033 | positive | 14(0.467) | 10(0.333) | 6(0.200) | 0.1221 |
| negative | 18(0.171) | 60(0.571) | 27(0.257) | 0.1211 | ||||
| C C | C T | T T | ||||||
| CYP2C9 | rs17885098 | 0.0222 | positive | 2(0.067) | 4(0.133) | 24(0.800) | 0.0205 | |
| negative | 0(0.000) | 10(0.095) | 95(0.905) | 0.6084 | ||||
| C C | C T | T T | ||||||
| ABCB1 | rs1128503 | 0.0305 | positive | 3(0.100) | 20(0.667) | 7(0.233) | 0.0503 | |
| negative | 13(0.124) | 42(0.400) | 50(0.476) | 0.3750 | ||||
| A A | A C | C C | ||||||
| CYP1A2 | rs762551 | 0.0058 | positive | 6(0.207) | 20(0.690) | 3(0.103) | 0.0338 | |
| negative | 51(0.515) | 36(0.364) | 12(0.121) | 0.1663 | ||||
| A A | A G | G G | ||||||
| CYP2C19 | rs4986893 | 0.0113 | positive | 1(0.036) | 5(0.179) | 22(0.786) | 0.3311 | |
| negative | 0(0.000) | 5(0.050) | 96(0.950) | 0.7987 | ||||
| A A | A G | G G | ||||||
| digestive tract injury induced by TKIs | CYP1A2 | rs2069521 | 0.0366 | positive | 1(0.033) | 3(0.100) | 26(0.867) | 0.0585 |
| negative | 0(0.000) | 24(0.123) | 171(0.877) | 0.3599 | ||||
| C C | C T | T T | ||||||
| CYP1A2 | rs4646425 | 0.0361 | positive | 26(0.867) | 3(0.100) | 1(0.033) | 0.0585 | |
| negative | 172(0.878) | 24(0.122) | 0(0.000) | 0.3613 | ||||
| C C | C T | C T | ||||||
| miRNA | rs111718468 | 0.0407 | positive | — | 3(0.100) | 27(0.900) | 0.7731 | |
| negative | — | 5(0.026) | 190(0.974) | 0.8561 | ||||