Figure 1. Mutation of Clec16a in mice induces locomotion deficits.

(a) Image demonstrating normal and aberrant responses hind limb clasping in wild-type and homozygous Clec16a^GT mice. (b) Age of mice during the hind limb test when they either scored a 1 (temporary clasping of one or more hind limb to body <30 seconds) or 2 (sustained clasping of both hind limbs to body <30 seconds). (c) Age of mice at which they dropped from the cage lid within 20 seconds of the lid being inverted. In (b) number of mice/group indicated in each graph; data were analyzed by Log-Rank (Mantel-Cox) test; ****P < 0.0001.