Extended Data Figure 11. In vivo behavioral profiling of GPR68 knock-out mice.

(a–b) No effects of GPR68 deletion on distance traveled in an open field. Data represent mean ± SEM for each group for a one-hour test session. (c–d) No difference on latency to fall from an accelerating rotarod. Data represent mean ± SEM for each group. (e–h) Decreased startle responses in GPR68 KO mice following presentation of acoustic stimuli (e, f). Data represent mean ± SEM for each group. No effects of genotype were found for levels of prepulse inhibition (g, h). Data represent means ± SEM for each group (*p<0.05). (i–l) No difference at acquisition and reversal learning in the Morris water maze. Data represent mean ± SEM of four trials per day. Subject numbers were 9 WT and 7 KO male mice, and 12 WT and 11 KO female mice.