Figure 3.

Expression of LOX in platelets affects thrombosis. (A) Carotid artery injury model of vascular thrombosis in WT (n = 9) and Pf4-Lox^tg/tg (n = 11) mice. Time to occlusion for each mouse is shown. *P < .001 by Student t test, difference of group means. (B) Representative flowchart of carotid artery blood flow. Interval of placement of filter paper soaked with FeCl₃ and time to occlusion (tOc) are indicated. (C) Typical images from serial sections of thrombi in carotid arteries. The thrombus is delineated with a dotted white line. Top images show thrombi in regions of carotid artery upstream from the injury site. The direction of the blood flow is denoted. Bottom images represent areas closer to the site of FeCl₃ injury (see “Methods”). Between 100 and 300 sections were stained and analyzed per mouse, using 11 Pf4-Lox^tg/tg mice and 8 WT mice.