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Vanin-1 as a sensor of oxidative stress. The Vanin-1 gene is regulated on stress induction, and the pantetheinase activity of the cell surface molecule provides tissue with cysteamine through the metabolism of pantothenate (vitamin B5). One major effect is the γGCS-mediated regulation of the endogenous GSH pool, influencing the redox status and therefore the cell fate in response to oxidative stress injury.
