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. 2016 Mar 17;47:44. doi: 10.1186/s13567-016-0329-x

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© Taha-Abdelaziz et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of dexamethasone on LPS-, Pam3CSK4- and IL-17A-induced up-regulation of TAP mRNA. Bovine tracheal epithelial cells were grown in the presence or absence of 10⁻⁶ M dexamethasone for 24 h. LPS (0.1 μg/mL), Pam3CSK4 (1 μg/mL) or IL-17A (316 ng/mL) were added for 16 h. Each of these agonists significantly upregulated TAP gene expression relative to the reference gene GAPDH (P < 0.001, two-way ANOVA of log-transformed data, Tukey’s post-test). The LPS-, Pam3CSK4- and IL-17A-induced upregulation were each abrogated by pre-treatment with dexamethasone (P < 0.001, two-way ANOVA of log-transformed data, Tukey’s post-test, n = 3 per group). Repetition of the experiment using cells from a different animal yielded similar findings.