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Evolutionary scenario explaining duplication events that gave rise to the different GHS‐R isoforms in vertebrates. Duplication in early vertebrate evolution (WGD1); fish‐specific whole‐genome duplication (WGD2); GHS‐R1a‐LR same than GHS‐R1a;GHS‐R2a lost in fish species other than Cypriniformes; (CA = Common ancestor).
