Fig. 4.

Complex regulatory interplay among transcription factors, miRNA 200 family members and E/M-phenotype related genes. Map created from genes differentially expressed between MCF-7-Snail and MCF-7-Control cells using MapEditor (Thomson Reuters, New York, NY, USA) to connect network objects based on previously reported associations. Legend for edges: TR transcriptional regulation, IE influence on expression, M microRNA binding. Green edge – activation; red edge repression. Edges originating or ending at SNAI1 are depicted as thick lines. Thermometers: red = network object up-regulated in MCF-7-Snail cells; blue = network object down-regulated in MCF-7-Snail cells; yellow = network object identified as over-connected to the list of differentially expressed genes. For more details on legend https://portal.genego.com/legends/MetaCoreQuickReferenceGuide.pdf