FIG. 6.

SPRET/Ei telomeres undergo the same elongation in wild-type and mTERT-transgenic B6 or (B6 × SPRET/Ei)F₁ mice. Telomeric repeat fragment distribution was analyzed by pulsed-field gel electrophoresis and in-gel hybridization of telomeric DNA from SPRET/Ei (Sp), B6, and (B6 × SPRET/Ei)F₁ mice with a wild-type genotype (WT) and/or the mTERT-transgene (+). The results shown are representative of those from six mTERT-transgenic (B6 × SPRET/Ei)F₁ mice from two independent transgenic lines. The boxed area represents elongated telomeres of parental SPRET/Ei origin. MK, molecular size marker; Tg, transgene.