TABLE 2.
Analysis of serum samples from 2-month-old wild-type (n = 6) and mKat-2−/− mice (n = 6)a
| Blood chemistry | Wild type | mKat-2−/− | Normal range |
|---|---|---|---|
| ALT (U/liter) | 68.7 ± 25.1 | 68.8 ± 14.3 | 24-140 |
| AST (U/liter) | 164.8 ± 64.2 | 86.3 ± 7.3 | 72-288 |
| GGT (U/liter) | 0.3 ± 0.3 | 0.0 ± 0.0 | 0-2 |
| Total bilirubin (mg/dl) | 0.1 ± 0.0 | 0.1 ± 0.1 | 0-0.9 |
| Direct bilirubin (mg/dl) | 0.0 ± 0.0 | 0.0 ± 0.0 | 0-0.2 |
| Total protein (g/dl) | 4.7 ± 0.1 | 4.7 ± 0.1 | 4.0-6.2 |
| Albumin (g/dl) | 2.6 ± 0.1 | 2.7 ± 0.3 | 2.6-4.6 |
| BUN (mg/dl) | 25.5 ± 3.3 | 23.3 ± 2.4 | 9-28 |
| Creatinine (mg/dl) | 0.3 ± 0.1 | 0.2 ± 0.0* | 0.2-0.7 |
a
Samples were obtained as described in the text and commercially analyzed (AniLytics). Analysis of liver and renal function included measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ- glutamyl transpeptidase (GGT), and blood urea nitrogen (BUN). Data are expressed as the mean ± SEM. *, P < 0.05 versus wild type (one-way ANOVA).