Figure 4.

Combining datasets in EMERGE outperforms classical enhancer hallmarks p300 and H3K27ac. Performance of enhancer prediction by EMERGE and heart H3K27ac and p300 ChIP-seq. Individual ChIP-seq datasets were sorted on significance. The combination of H3K27ac and p300 and EMERGE without these three datasets are also plotted. Enhancers active in other tissue were used as negative control region reference data. The dashed line indicates the fraction of reporter assays that will detect a true enhancer when a false positive rate of 10% is accepted (see Table 1).