Table 3. Mean ALT levels measured daily up to 96 h. Number of mRNA transcripts modulated by each LNA ASOs as a function of dose 24 h after administration.

				ALT (IU/ml)				Number of transcripts modulated at 24 h
ASO ID	Alternative ID	Dose (mg/kg)	Toxicity (96 h)	24 h	48 h	72 h	96 h	Down (−2x, P-value ≤ 0.01)	Up (2x, P-value ≤ 0.01)
569713	ASO ctrl	33	Safe	49	21	20	23	0	1
		300	Safe	32	25	25	27	19	14
569714	FXI-4	33	Safe	23	18	25	32	0	1
		300	Safe	41	26	32	30	27	8
571035	FVII-1	33	Safe	24	22	24	19	1	0
		300	Safe	76	28	63	93	11	4
569715	SOD1—1	33	Safe	32	26	30	39	1	0
		300	Safe	34	20	30	87	121	20
571033	FXI-3	33	Safe	28	20	24	33	1	0
		300	Safe	32	22	65	121	111	10
571034	FXI-5	33	Safe	34	21	25	56	1	0
		300	Safe	237	29	86	193	96	10
554219	BIRC5	33	Safe	187	22	37	33	20	9
		300	Severe	29	69	1239	1475	418	114
569716	FVII-2	33	Safe	31	20	28	128	5	1
		300	Severe	30	39	4038	4690	282	43
569718	FVII-3	33	Moderate	25	22	100	461	140	8
		100	Severe	29	123	3880	5034	568	173
569720	FXI-2	33	Safe	22	23	35	125	87	34
		100	Severe	26	129	4960	10 179	392	167
569717	PTEN	33	Severe	44	36	187	1143	86	4
		100	Severe	27	130	2067	10 262	397	101
569721	SOD1–2	33	Severe	30	337	878	2288	867	394
569719	FXI-1	11	Severe	50	59	183	1486	318	159
		33	Severe	47	3983	10 771	20 000	1301	998