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Competition between Bac7 derivatives and erythromycin. (A) Superimposition of the binding site of erythromycin (blue) (40,41) with residues 11–16 of Bac7(1–16) (green). (B) A filter binding assay was used to monitor competition between radiolabelled [14C]-erythromycin and increasing concentrations (1–100 μM) of Bac7(1–35) (red), Bac7(1–16) (green), Bac7(5–35) (blue), Onc112 (grey) and cold (non-radioactive) erythromycin (ery, black).
