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. 2016 Jan 24;44(5):2439–2450. doi: 10.1093/nar/gkw018

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Conformation of the N-terminal region of PrAMPs in the ribosome. (A) The N-terminal of Bac7₁_–35 (brown) extends further than Onc112 (green) [PDB ID: 4Z8C (27)] into the A site of the 50S subunit, establishing interactions with H89 of 23S rRNA. (B) The N-terminal of Bac7₁_–35 is not compatible with the presence of the CCA-end of an A-site tRNA (light blue) [PDB ID: 4Y4P (69)]. (C) The Asp2 residue at the N-termini of PrAMPs Pyrrhocoricin, Metalnikowin, Onc10wt, OncΔ15–19 and Onc112 [PDB ID: 4Z8C (27)] interact with the Watson–Crick edge of nucleotide G2553 in the 23S rRNA A-loop.