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. 2016 Jan 24;44(5):2439–2450. doi: 10.1093/nar/gkw018

Figure 4.

Figure 4.

Interactions of the N-terminal (A–E) and the core (middle) (F) regions of Bac71–35 with the ribosome. Residues Arg1 (A), Arg2 (B), Arg4 (C) and Arg6 (D) establish multiple interactions with nucleotides in H89 and H92 of 23S rRNA. Each arginine residue of the N-terminal 'RRIR' motif in Bac71–35 participates in dual interactions involving the epsilon nitrogen and the amino group. (E) Four-layer π-stacking interaction formed between residues Arg2, Arg6, Arg4 and nucleotide C2573. (F) Residue Arg9 of the core region in Bac71–35 stacks with the conserved base pair formed between nucleotides C2452 and U2504 of the A-site cleft and also forms a hydrogen bond with G2061. The Leu10 residue stacks with residue Arg9.