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. 2016 Jan 24;44(5):2439–2450. doi: 10.1093/nar/gkw018

Figure 5.

Figure 5.

Interactions of the C-terminal region of Bac71–35 with the upper chamber of the peptide exit tunnel. (A) Residue Arg16 forms a π-stacking interaction with His69 of ribosomal protein uL4 and also makes multiple interactions with the ribosome. (B) The interactions mediated by residue Arg16 in Bac71–35 (brown) are compensated by Arg11 in Onc112 (green) [PDB 4Z8C (27)]. (C) Residue Arg14 stacks with nucleotide C2586 and the main chain peptide backbone of residues 17–19 forms a stacking interaction with nucleotides C790 across the tunnel, and with residue Arg90 of ribosomal protein uL22. (D) Lateral displacement of the C-terminus of Pyrrhocoricin (red) compared with Bac71–35 (brown) by more than 5 Å along the constriction formed by the loops of proteins uL4 and uL22.