Table 2. Minimal inhibitory concentration (MIC) values for selected PrAMPs against E. coli strains.
Peptide | SQ110 (LPTD) (μM) | SQ110 (μM) |
---|---|---|
Bac71–35 | 0.75 | 1.5 |
Onc112 | 0.75 | 12.5 |
Pyrrhocoricin | 4 | >25 |
Metalnikowin | 62.5 | >25 |
OncΔ15–19 | 25 | >25 |
OncΔVD | 62.5 | >25 |
Onc10wt | 1 | 25 |
The SQ110 LPTD strain is defective in the lipopolysaccharide assembly of the outer membrane and is more sensitive to some antibiotics (53).