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. 2016 Feb 2;44(5):2451–2461. doi: 10.1093/nar/gkw029

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Specificity of Screened FQ responsive promoter. Response of Nal inducible promoter to various stress inducing agents. E. coli RFM443 cells harboring reporter plasmid pNal::ibsC and pRx::ibsC were treated with sub-lethal concentration of different chemical ligands [cadmium chloride (CdCl₂), sodium aresenite (Na₂AsO₂), ethanol, norfloxacin (Norf), ciprofloxacin (Cipro), tetracycline (Tet), chloramphenicol (Chl), Mitomycin C (MMC), Novobiocin and polymyxin B (Poly-B)] which trigger stress response in the cell. Ciprofloxacin and norfloxacin (DNA GyrA inhibitors) activated pNal::ibsC reporter system and resulted in cell death. Other chemical ligands (cadmium chloride, sodium arsenite, ethanol, tetracycline, chloramphenicol, MMC and poly-B) having different mode of action were unable to induce similar response in test and control plasmids (pRx::ibsC).