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. 2016 Feb 11;44(5):2274–2282. doi: 10.1093/nar/gkw076

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — A distal hotspot in the PR promoter for RNAa. (A) Schematic representation of 30 tiled saRNAs with each target shifted 1-nt around PR-1611. All potential targets of small RNAs in the region from −1626 to −1596 are included (the TSS is regarded as +1). (B) Plot of PR mRNA expression levels in MCF-7 cells after individual transfection with 30 tiled saRNAs. Cells were harvested after 72 h. PR mRNA expression levels were assessed by qPCR and normalized to GAPDH. The results are mean ± SEM of at least three independent experiments and plotted as relative expression compared to NC transfection. *P < 0.05; **P < 0.01; ***P < 0.001.