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. 2016 Feb 15;44(5):1989–2006. doi: 10.1093/nar/gkw079

Figure 2.

Figure 2.

Possible roles of DNA G-quadruplex in transcription by RNA polymerase (orange) (39). (A) Blocking transcription: transcription is inhibited due to the formation of a stable G-quadruplex. (B) Facilitating transcription: formation of a stable G4 in the complementary strand enhances transcription. (C) Stimulating transcription: G-quadruplex binds proteins (blue) that stimulate the transcription process. (D) Repressing transcription: G-quadruplex binds protein that repress transcription directly (green) or via other proteins (blue).