TABLE 3.

Chromosome aberrations

Genotype	No. of metaphases analyzed	No. of chromosomes per metaphase (mean ± SDsc)	No. of chromosome breaks	No. of chromatid breaks	No. of fragmentsa	No. of other aberrationsb	No. (%) of metaphases with aberrations
Mrad9+/+	106	41.40 ± 0.5	0	0	0	0	0
Mrad9Tar/−	110	41.2 ± 1.0	1 (0.01/cell)	1 (0.01/cell)	0	1 (0.01/cell)	3 (2.73)
Mrad9−/−	106	40.94 ± 1.0	6 (0.06/cell)	3 (0.03/cell)	8 (0.08/cell)	8 (0.08/cell)	14 (13.21)
Mrad9−/−, pZeoSV2-Mrad9	106	40.6 ± 0.9	0	0	1 (0.01/cell)	1 (0.01/cell)	2 (1.89)
Mrad9−/−, pZeoSV2-HRAD9	110	41.2 ± 0.7	2 (0.018/cell)	1 (0.009/cell)	1 (0.009/cell)	1 (0.009/cell)	2 (1.82)

^aCentric and acentric fragments and interstitial deletions included.

^bFusions included.

^cSD, standard deviation.