TABLE 1.
FTI dose influences the number and primitiveness of H-Ras-expressing CFCs
| Vector | FTI treatment (nM) | Relative colony counta | % Primitive CFU-Mb |
|---|---|---|---|
| MSCV-Neo | 0 | 1 | 1.7 ± 3.0 |
| 25 | 1.01 ± 0.09 | 1.6 ± 2.4 | |
| 50 | 0.98 ± 0.08 | 1.5 ± 4.1 | |
| 100 | 0.91 ± 0.09 | 1.0 ± 2.1 | |
| 200 | 0.9 ± 0.11 | 1.8 ± 4.5 | |
| 400 | 0.9 ± 0.08 | 1.9 ± 3.5 | |
| MSCV-H-Ras-Neo | 0 | 1 | 2.8 ± 2.9 |
| 25 | 1.64 ± 0.21 | 10.2 ± 6.1 | |
| 50 | 2.01 ± 0.29 | 15.0 ± 7.7 | |
| 100 | 2.49 ± 0.48 | 15.1 ± 8.7 | |
| 200 | 1.93 ± 0.51 | 16.9 ± 7.4 | |
| 400 | 1.03 ± 0.32 | 9.3 ± 6.2 |
a
Number of colonies formed relative to the number formed without treatment. Values are means±SD.
b
Percentage of primitive monocytic colonies (high level of colony cellularity and high number of phenotypically primitive cells). Values are means ± SD.