Table 3.
Potential therapeutic miRNAs for ovarian cancer
| miRNA | Target gene | Cell line | Cellular function | References |
|---|---|---|---|---|
| miR-484 | VEGFB, VEGFR2 | MDAH-2774 (EOC), SKOV-3 (EOC) | Angiogenesis | [42], 2013 |
| miR-92a | ITGA5 | HeyA-8 (SAC), SKOV3ip1 (SAC), OVISE (CAC), RMG-1 (CAC), A2780 (SAC), CaOV3 (SAC) | Adhesion, migration | [43], 2013 |
| miR-200a, miR-200b | IL-8, CXCL1 | OVCAR8-ip1 (SAC), ES2 (SAC), HeyA-8 (SAC), OVCAR5 (SAC), A2780 (SAC), A2774 (SAC), IGROV1-ap1 (SAC), SKOV3ip1 (SAC) | Angiogenesis, migration | [44], 2013 |
| miR-506 | CDK4, CDK6 | SKOV3 (EOC), OVCA432 (EOC), OVCA433 (EOC), HeyA-8 (SAC) | Proliferation, senescence | [45], 2014 |
| miR-199b-5p | JAG1 | A2780 (EOC), SKOV3 (EOC), ES 2 (EOC) | Chemoresistance | [46], 2014 |
| miR-939 | APC2 | SKOV-3 (EOC), CAOV-3 (EOC), HO-8910 (EOC), ES-2 (EOC), A2780/DDP (EOC) | Proliferation | [47], 2015 |
| miR-661 | INPP5J | COV362 (EOC), SKOV3 (EOC), A2780 (EOC), OVCAR4 (EOC), EFO-21 (EOC), EFO-27 (EOC), TOV-21G (EOC), OV90 (EOC), OV56 (EOC) | Proliferation | [48], 2015 |
| miR-205 | VEGFR1, VEGFR2 | HO-8910PM (SAC), SKOV-3ip (SAC) | Invasion | [49], 2015 |
EOC: Epithelial ovarian carcinomas; SAC: Serous adenocarcinoma; CAC: Clear cell adenocarcinoma; miRNAs: MicroRNAs.