Table 3.
Sensitivity, specificity, PPV and NPV of the spinal cord MRI features of LETM for distinguishing NMO from other etiologies including MS.
| Centrally- located lesion |
Lesion >1/2 of the cord area |
T2 bright, spotty lesions |
Contrast enhancement |
T1 dark | |
|---|---|---|---|---|---|
| Sensitivity, % | 97.9 | 93.8 | 64.6 | 64.6 | 54.2 |
| Specificity, % | 21.7 | 30.4 | 89.1 | 60.9 | 76.1 |
| PPV, % | 56.6 | 58.4 | 86.1 | 63.3 | 70.3 |
| NPV, % | 90.9 | 82.4 | 70.7 | 62.2 | 61.4 |
LETM: Longitudinally extensive transverse myelitis; MRI: magnetic resonance imaging; MS: multiple sclerosis; NMO: neuromyelitis optica; NPV: negative predictive value; PPV: positive predictive value.