Table 1. Summary of DMN findings in neurological and neuropsychiatric conditions.

Alzheimer's disease (AD)
Major Findings	Effects of Treatment	Future Directions
1. Decreased functional connectivity between posterior and anterior portions of the DMN [28-31]	Increased DMN connectivity after memantine and donepezil treatment [16,40,41]	Early detection, development of novel targeted treatments using DMN assessments
2. Overlap between the DMN and patterns of amyloid deposits [16,37,38]
Parkinson's Disease (AD)
Major Findings	Effects of Treatment	Future Directions
1. Coordinated activity of striatum and the DMN [45]	Normalization of DMN function after administration of levodopa [58]	Early detection, development of novel targeted treatments using DMN assessments
2. Network disruptions in the DMN and CEN — heightened activation and dysfunctional connectivity [46]
3. Visual hallucination-related increased DMN connectivity [56,57]
Temporal Lobe Epilepsy (TLE)
Major Findings	Effects of Treatment	Future Directions
1. Disrupted functional connectivity between the mesial temporal lobe and DMN regions, related to cognitive and psychiatric impairments [61,64-69]	Potential relationship between GABAergic and glutamatergic dysfunction and altered DMN connectivity [70]	Potential role of DMN assessment in treatment development
2. Distinct patterns of the DMN connectivity depending on the laterality of TLE [13]
3. Variations in DMN connectivity depending on seizure phase [14]
Attention deficit hyperactivity disorder (ADHD)
Major Findings	Effects of Treatment	Future Directions
1. Correlation between maintained DMN activation and impaired task performance [73,74]	Normalization of disrupted connectivity between the cognitive control network and the DMN after treatment with atomoxetine and methylphenidate [74,81]	Studies of treatment effects and bio-typing
2. Attenuated negative connectivity between the cognitive control network and the DMN [20,75,77-79]
3. Attenuated negative connectivity between the putamen and the DMN [75,80]
Mood Disorders
Major Findings	Effects of Treatment	Future Directions
1. Dysfunctional connectivity in the DMN and its relation to symptoms (especially rumination) [82-85,88]	Normalization of DMN function after antidepressant medication treatment in MDD [89]	Relationships between symptoms or dimensions in mood disorders and DMN function along with treatment effects
2. Correlation between the duration and number of the depressive episodes and disrupted DMN connectivity [10,86]