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. Author manuscript; available in PMC: 2016 Mar 18.
Published in final edited form as: Science. 2005 Apr 14;308(5728):1643–1645. doi: 10.1126/science.1110656

Fig. 3.

Fig. 3

Endosomal cysteine protease inhibitors diminish EboV-Zaire multiplication in Vero cells. (A) Yields of infectious EboV-Zaire released from cells treated with DMSO (no drug), 300 μM E-64d (to inactivate endosomal cysteine proteases), or 80 μM CA074 (to selectively inactivate CatB) for 4 hours are shown. Growth medium containing inhibitors was removed from cells at the indicated time (arrowhead) and replaced with fresh medium lacking inhibitors. pfu/ml, plaque-forming units per milliliter; h p.i., hours post infection. Averages from two replicates are shown. (B) GP expression in EboV-infected cells from (A). β-actin was used as a loading control.