Table 2.
Comparison of serum markers of inflammation and bone turnover between those normal BMD and those with hepatic osteodystrophy (e.g., osteopenia/osteoporosis)
| Markera | All | Normal BMD | Low BMD | p value |
|---|---|---|---|---|
| n = 60 | n = 35 | n = 25 | ||
| Inflammation | ||||
| ALT (U/L) | 60.3 (35.0) | 62.6 (37.0) | 57.0 (33.7) | 0.55 |
| % with ALT ≤ 42 U/L | 20 (33 %) | 12 (34 %) | 8 (32 %) | 0.86 |
| % with ALT 43–74 U/L | 24 (40 %) | 13 (37 %) | 11 (44 %) | |
| % with ALT ≥ 75 U/L | 16 (27 %) | 10 (29 %) | 6 (24 %) | |
| High-sensitivity CRP (mg/L) | 0.8 (1.5) | 0.7 (1.0) | 0.8 (2.0) | 0.82 |
| % with elevated hsCRP (≥3 mg/L) | 3 (5 %) | 2 (6 %) | 1 (4 %) | 0.76 |
| TNF-α (pg/mL) | 5.2 (9.0) | 4.6 (8.1) | 5.9 (10.2) | 0.57 |
| % with elevated TNF-α (≥6 pg/mL) | 16 (26 %) | 8 (22 %) | 8 (31 %) | 0.43 |
| IL-6 (pg/mL) | 21.0 (68.3) | 16.5 (40.4) | 27.4 (95.3) | 0.55 |
| % with elevated IL-6 (≥7 pg/mL) | 20 (32 %) | 12 (33 %) | 8 (31 %) | 0.96 |
| Bone turnover, calciotropic hormones and minerals | ||||
| Calcium (mg/dL) | 9.3 (0.5) | 9.3 (0.5) | 9.1 (0.4) | 0.08 |
| Phosphorus (mg/dL) | 3.8 (0.9) | 3.5 (0.5) | 4.1 (1.2) | 0.04 |
| Calcium–phosphorus product | 34.8 (8.9) | 33.0 (4.5) | 37.1 (12.0) | 0.08 |
| 25(OH) vitamin D (ng/mL) | 29.6 (14.9) | 31.0 (16.3) | 27.8 (12.9) | 0.42 |
| % with 25(OH)D <20 ng/mL | 18 (30 %) | 9 (26 %) | 9 (36 %) | 0.39 |
| Total alkaline phosphorus (U/L) | 74.3 (22.0) | 72.2 (18.1) | 77.3 (26.6) | 0.38 |
| iPTH (pg/mL) | 42.3 (62.5) | 46.7 (81.1) | 36.1 (14.9) | 0.52 |
| Bone-specific alkaline phosphorus (U/L) | 22.9 (8.6) | 21.6 (7.4) | 24.7 (9.9) | 0.18 |
| Z score BSAP | 1.8 (1.5) | 1.8 (1.6) | 2.0 (1.5) | 0.68 |
| C-telopeptide (pg/mL) | 378.1 (277.7) | 331.1 (253.7) | 443.9 (301.1) | 0.12 |
| Z score C-telopeptide | −0.8 (1.2) | −0.9 (1.3) | −0.7 (1.0) | 0.59 |
| P1NP (ng/mL) | 58.2 (35.2) | 47.5 (15.7) | 73.1 (48.0) | <0.01 |
| Z score P1NP | −0.8 (1.4) | −1.2 (0.6) | −0.2 (1.9) | <0.01 |
a
Mean (standard deviation) or n (%)