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. Author manuscript; available in PMC: 2016 Mar 18.
Published in final edited form as: Semin Liver Dis. 2015 Jan 29;35(1):3–11. doi: 10.1055/s-0034-1397344

Figure 2. Alternative microRNA targeting.

Figure 2

Multiple instances may arise in which microRNAs can no longer bind to their intended targets. Three examples are: 1) Alternative splicing - the microRNA binding site is spliced out of the target transcript; 2) Alternative polyadenylation signals - short 3′UTRs lack the microRNA binding site; and 3) Single nucleotide polymorphisms - altered microRNA binding sequence in the target mRNA inhibiting binding site recognition.