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. Author manuscript; available in PMC: 2016 Mar 18.
Published in final edited form as: ILAR J. 2011;52(3):352–365. doi: 10.1093/ilar.52.3.352

Figure 2.

Figure 2

Effects of reserpine or clorgyline on levels of (A) tyrosine hydroxylase (TH) and (B) dopamine transporter (DAT) in the nucleus accumbens (NAc) of mice treated with a neurotoxic methamphetamine (Meth) regimen. Mice (n = 5–8 per group) were treated with Meth alone, reserpine (Res) + Meth, or clorgyline (Clorg) + Meth as described in the text. NAc TH and DAT protein levels were determined by western blot analysis at the indicated times post-Meth and are presented as means ± SEM relative to control. Mice treated with clorgyline + Meth were tested only at the 2d time point. Significant differences were determined via one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test: **, p < 0.01, and ***, p < 0.001 relative to control; #, p < 0.05 indicates significant differences between indicated treatment conditions. Reprinted with permission from Thomas et al. (2009).