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. Author manuscript; available in PMC: 2016 Mar 18.
Published in final edited form as: ILAR J. 2011;52(3):352–365. doi: 10.1093/ilar.52.3.352

Figure 3.

Figure 3

Effects of clorgyline, L-DOPA, and reserpine on microglial activation in the nucleus accumbens (NAc) caused by a neurotoxic methamphetamine (Meth) regimen. Mice (n = 3–5 per group) were treated as described in the text and analyzed for microglial activation in the NAc 48 h after the last Meth injection. Microglia counts are presented as means ± SEM. Treatment conditions and microglia counts for each panel are (A) control (5 ± 1), (B) Meth (15 ± 2), (C) clorgyline + Meth (61 ± 5), (D) L-DOPA + Meth (58 ± 6), (E) reserpine + Meth (66 ± 6), and (F) reserpine only (8 ± 1). Significant differences were determined via one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test: p < 0.001 for clorgyline + Meth, L-DOPA + Meth, and reserpine + Meth relative to control. No significant differences were determined for Meth or reserpine only relative to control (p > 0.05). Reprinted with permission from Thomas et al. (2009). The color image is available in the online posting of this article at www.ilarjournal.com.