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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Aug 25;54(41):11930–11944. doi: 10.1002/anie.201502890

Figure 9.

Figure 9

Proposed mechanism of replication of d5SICS-dNaM UBP. Intermediates based on solved structures are shown in darker color and those not yet validated by structural studies are shown in lighter color. The steps corresponding to incorporation of the unnatural triphosphate and subsequent extension of the nascent UBP are indicated. Phosphates are indicated with open circles, natural nucleotides are indicated with open rectangles, and the unnatural nucleotides are indicated with grey and black boxes. Reproduced from Betz, et al.[167]