Figure 3.
PAH decreases gene expression of anti-apoptotic Bcl-xL in the RV. Rats were subjected to SU5416/hypoxia treatment (8-week time point). Protein expression of (A) Bcl-xL, (B) Bax, (C) GATA4, and (D) p53 were monitored by western blotting in the RV. The symbol (*) denotes that the values are significantly different from each other at P < 0.05 as determined by one-way ANOVA. The symbol (**) indicates that the value is significantly different from the control value at P < 0.05 as determined by Student's t-test.