Fig 1. A low-frequency SNP within MERTK is significantly associated with MS susceptibility.

124 SNPs on chromosome 2 were directly genotyped in 3268 MS cases and 3579 controls. (A) The negative log of the unadjusted p-value of each SNP is plotted against the relative position on chromosome 2, with a schematic of the gene structures shown underneath (B). Two SNPs, both within MERTK, reach significance using the Sidak adjustment for multiple testing at a nominal α = 0.05. Association p-values were determined using a Chi-square test. (C) Schematic of the pattern of LD across the whole region, with a large single block of high LD (D'>0.99), including the whole of the MERTK gene, highlighted with a red triangle.