Skip to main content
. 2016 Mar 18;12(3):e1005853. doi: 10.1371/journal.pgen.1005853

Fig 5. Discordant effect of rs7422195 in the presence or absence of HLA-DRB1*15:01.

Fig 5

All samples (n = 3000) were first stratified according to the number of DR15 alleles then by genotype at rs7422195. (A) The frequency of the A-allele of rs7422195 was calculated for cases and controls within each DR15 genotype group, showing a clear decrease in the frequency of the A-allele with increasing copies of DR15 within MS cases, and the opposite effect in healthy controls. The total number of samples within each DR15 genotype group is included below the group name on the x-axis, with the number of individuals used to calculate each point represented in brackets on the graph. (B) Disease frequency for each group was calculated as the number of MS cases divided by the total number of cases and healthy controls for each genotype. The minor allele at rs7422195 shows an increase in the disease risk in the absence of DR15, but a clear decrease in the disease frequency amongst individuals carrying two copies of DR15.