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. 2016 Mar 18;12(3):e1005853. doi: 10.1371/journal.pgen.1005853

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© 2016 Binder et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 8 — Individuals initially presenting with a relapsing-remitting course of MS were stratified by both DR15 status and genotype at rs7422195. (A) In the presence of the minor (A) allele of rs7422195, DR15 negative individuals (n = 370) showed a strong trend towards increased probability of progression (p = 0.07) (B) In the presence of the major (G) allele of rs7422195 DR15 homozygous individuals (n = 68) showed a strong trend towards increased probability of progression (p = 0.081)