Table 1. Chromosomal damage in lymphocytes from PALB2 patient II-5 and controls.

Total number of Cells	Number of Rings	Number of Dicentrics	Number of Fragments	Number of Chromatid gaps	Number of Chromatid Breaks	Number of Tri-radials	Number of Quadri-radials	Number of Multi-radials
(1) Patient blood—untreated
50	0	2	2	8	1	0	0	0
(2) Following exposure to 0.1μgml-1 mitomycin C for 4h and cultured to 48h Patient II-5
50	1	2	2	27	20	8	8	3
Normal control
50	0	0	0	0	0	0	0	0
Three typical Fanconi anaemia patients
50	0	0	0	22	11	4	5	0
50	0	0	0	26	21	10	10	0
50	0	0	0	16	19	0	1	0
(3) Following exposure to 1.0 Gray γ-rays@ G2 Patient II-5
50	1	3	4	81	54	29	18	9
Normal control
50	0	0	0	6	0	0	0	0
Two classical ataxia telangiectasia patients (positive control)
50	0	0	0	65	18	1	1	0
50	0	0	0	49	29	1	2	0