Table 7. Sensitivity Analysis: Projected Cost and Time to Treatment Initiation, Incremental Cost (savings) and Treatment Days Gained, and Incremental Cost per Treatment Days Gained, per Individual Evaluated for TB, in Nunavut, Canada.
| Status Quo | Gene Xpert®MTB/RIF Added | Gene Xpert®MTB/RIF vs Status Quo | |||||
|---|---|---|---|---|---|---|---|
| $ per Individual evaluated for TB | Time to treatment initiation | $ per Individual evaluated for TB | Time to treatment initiation | *Incremental cost | Treatment days gained | Incremental cost per treatment day gained | |
| Base Case | |||||||
| Iqaluit Hospital Community | 5261 | 1.3 | 5455 | 0.7 | 194 | 0.6 | 340 |
| Remote Nunavut Community | 1486 | 1.8 | 1576 | 1.2 | 90 | 0.6 | 145 |
| Full Cohort | 2278 | 1.7 | 2390 | 1.1 | 100 | 0.6 | 164 |
| Sensitivity Analysis 1: 3 specimens analyzed with Xpert®MTB/RIF per individual | |||||||
| Iqaluit Hospital Community | 5261 | 1.3 | 5510 | 0.5 | 249 | 0.8 | 304 |
| Remote Nunavut Community | 1486 | 1.8 | 1633 | 1.0 | 147 | 0.9 | 169 |
| Full Cohort | 2278 | 1.7 | 2447 | 0.9 | 169 | 0.9 | 197 |
| Sensitivity Analysis 2a: Hospital discharge for those started on empiric therapy who are Xpert®MTB/RIF negative- 1 specimen analyzed with Xpert®MTB/RIF | |||||||
| Iqaluit Hospital Community | 5261 | 1.3 | 2960 | 0.7 | -2301 | 0.6 | Saving |
| Remote Nunavut Community | 1486 | 1.8 | 982 | 1.2 | -504 | 0.6 | Saving |
| Full Cohort | 2278 | 1.7 | 1397 | 1.1 | -881 | 0.6 | Saving |
| Sensitivity Analysis 2b: Hospital discharge for those started on empiric therapy who are Xpert®MTB/RIF negative- 3 specimens analyzed with Xpert®MTB/RIF | |||||||
| Iqaluit Hospital Community | 5261 | 1.3 | 3349 | 0.5 | -1912 | 0.8 | Saving |
| Remote Nunavut Community | 1486 | 1.8 | 1061 | 1.0 | -425 | 0.9 | Saving |
| Full Cohort | 2278 | 1.7) | 1541 | 0.9 | -727 | 0.9 | Saving |
* Negative incremental cost indicates "Savings" with Xpert®MTB/RIF strategy relative to the Status Quo strategy