Figure 3.

Distribution of variant alleles in cancer stem cells (CSCs). (A): Frequency distribution patterns for the annotated germline inherited (solid line) and somatically acquired (dashed line) variants in a representative subset of CSC lines. (B): Mutational signatures of the same CSC lines as in (A). Each signature is displayed according to the 96 substitution classification defined by the substitution class and sequence context immediately 3′ and 5′ to the mutated base. Bars for the six types of substitutions are displayed in different colors. Abbreviation: SNV, single-nucleotide variant.