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. 2016 Mar 8;5(4):511–523. doi: 10.5966/sctm.2015-0214

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Figure 6. — Reverse phase proteomic array (RPPA) for the identification of pathways differently activated in anti-epidermal growth factor receptor-sensitive and -resistant CSC. (A): Highly responsive (CSC1) and resistant (CSC8) CSC lines were treated with cetuximab and analyzed at different time points by RPPA. Statistical analysis of unsupervised clustering identified 27 endpoints differentially modulated in CSC1 and CSC8. Time-course plots (B) and Western blot validation (C) of eight relevant pathway effectors. Abbreviations: CETU, cetuximab; CSC, cancer stem cell.