Table 1. Characteristics of Patients with Stage III NSCLC by Esophagitis and pneumonitis Status.
| Characteristics | Esophagitis Status | Pneumonitis Status | ||||
|---|---|---|---|---|---|---|
| Event | No event | p | Event | No event | p | |
| Age, mean(SD) | 60.65 (10.04) | 62.83 (9.94) | 0.203 | 62.55 (9.46) | 60.63 (9.97) | 0.234 |
| Smoking Pack year, mean(SD) | 47.87 (29.63) | 42.41 (24.44) | 0.259 | 47.32 (32.04) | 45.05 (24.37) | 0.616 |
| DLCO(mL), mean(SD) | 70.32 (16.90) | 70.29 (22.70) | 0.997 | 67.67 (15.25) | 72.54 (21.24) | 0.441 |
| FEV1(mL), mean(SD) | 73.96 (17.52) | 71.59 (19.74) | 0.682 | 72.13 (15.34) | 73.62 (20.41) | 0.803 |
| PTV(mL), mean(SD) | 908.50 (504.64) | 728.21 (452.80) | 0.106 | 844.00 (561.11) | 846.57 (473.85) | 0.982 |
| Mean Esophageal Dose (Gy) mean(SD) | 36.79 (10.69) | 30.62 (9.32) | 0.004* | 35.52 (11.76) | 34.25 (10.38) | 0.569 |
| Mean Lung Dose (Gy) mean(SD) | 21.31 (9.3) | 18.05 (4.4) | 0.048 | 23.03 (11.98) | 18.86 (5.22) | 0.015* |
| Sex | ||||||
| Male, n (%) | 64 (54) | 27 (56) | 0.772 | 31 (52) | 53 (55) | 0.717 |
| Female, n (%) | 55 (46) | 21 (44) | 29 (48) | 44 (45) | ||
| Clinical Stage of Disease | ||||||
| IIIA, n (%) | 64 (54) | 28 (58) | 0.593 | 36 (60) | 52 (54) | 0.432 |
| IIIB, n (%) | 55 (46) | 20 (42) | 24 (40) | 45 (46) | ||
| Performance status | ||||||
| 0, n (%) | 41 (34) | 10 (21) | 0.161^ | 18 (30) | 31 (32) | 0.417^ |
| 1, n (%) | 52 (44) | 27 (56) | 29 (48) | 43 (44) | ||
| 2~4, n (%) | 8 (7) | 6 (13) | 3 (5) | 11 (11) | ||
| Missing, n (%) | 18 (15) | 5 (10) | 10 (17) | 12 (12) | ||
| Chemotherapy | ||||||
| concurrent chemoradiotherapy, n (%) | 117 (98) | 44 (92) | 0.057^ | 58 (97) | 93 (96) | 1^ |
| Others, n (%) | 2 (2) | 4 (8) | 2 (3) | 4 (4) | ||
| Radiotherapy type | ||||||
| 2D, n (%) | 31 (26) | 12 (25) | 0.021^* | 14 (23) | 28 (29) | 0.578^ |
| 3D, n (%) | 56 (47) | 14 (29) | 29 (48) | 36 (37) | ||
| IMRT, n (%) | 29 (24) | 16 (33) | 15 (25) | 27 (28) | ||
| Proton, n (%) | 3 (3) | 6 (13) | 2 (3) | 6 (6) | ||
DLCO: Carbon Monoxide Diffusing Capacity
FEV1: expiratory volume in 1 second
PTV: planning target volume
IMRT: Intensity-modulated radiation therapy
^ Fisher's exact test
*p<0.05.